About The Human RNome Project
Our goal
The Human RNome Project aims to sequence full-length RNA transcripts with all their chemical modifications. The technologies we develop will enable direct sequencing of any RNA from any organism. These advances will have wide-ranging impact—from fundamental biology to applications in manufacturing, data storage, and therapeutics.
Introduction
The Human RNome Project is a global effort to reveal the complete landscape of human RNA biology. Beyond their DNA templates, RNAs are extensively modified—over 50 distinct chemical marks have been identified in human cells—altering their function in health and disease.
With more than 20,000 human diseases and effective treatments for only about 500, the RNome holds untapped potential for understanding disease mechanisms and developing novel therapies. Advances in RNA-based medicines, from Nusinersen for spinal muscular atrophy to mRNA cancer treatments, demonstrate what is possible when RNA is understood and targeted precisely.
By providing the first comprehensive, modification-resolved view of the human RNome, this project will create a foundation for new discoveries, spur innovation across biology and manufacturing, and open new frontiers in therapeutic development.